Dr. Suneil Jain, N.M.D.

Scottsdale Natural Medicine and Healing Clinic, LLC, 8390 E. Via de Ventura Blvd. Suite F-111 Scottsdale, AZ 85258

 

Preliminary Study

To evaluate the safety, tolerability and effectiveness of transdermal delivery of a Hyaluronic Acid cocktail on Perioribital & Perioral Areas through Dermoelectroporation®.

Study Design

• Fine to medium lines of the face
• Treatments should be administered every 2 weeks for 3 treatments. Thereafter every 6-8 weeks for maintenance.
• L-Carnitine/Phosphatidylcholine cocktail was
  delivered
• Ultrapeel® Transderm® Meso System
• Session number depending on the single patient’s condition
• Study conclusion on 90% or more resolution

 

Materials and Methods

Materials

1. Hyaluronic Acid – plays an important role in tissue hydration, lubrication and cellular function; removes wastes from cells with no direct blood supply; able to hold more water than any other natural substance which results in smoothness, softening and decrease in wrinkles

2. Glutathione – “master antioxidant”; acts to reconstitute Vitamin C and E after they have been oxidized; protects cells from free radical damage; works in conjunction with Super Oxide Dismutase (enzymes that play a major role in the protection of cells from oxidative stress) to help with detoxification

3. MTE-4 – contains 4 multi-trace elements

a. Copper: important for conversion of Ltyrosine to melanin aiding in UV protections; needed for conversion of carotene to retinol; needed for CT maturation; provides cross-linking of aldehydes in collagen and elastin tissues; stimulates SOD enzyme

b. Manganese: activates enzymes in formation of collagen; tones & firms skin

c. Zinc Sulfate: required for synthesis of collagen; protects against UV rays; stimulates transport of Vitamin A from liver to skin; stimulates SOD enzyme d. Chromium: can help with acne by improving localized glucose sensitivity 4.Ultrapeel® Transderm Meso® system from Mattioli Engineering

Methods

• Transdermal delivery of the cocktail through Dermoelectroporation® technology:
• 2 Steps Procedure:
  a)Microdermabrasion
  b) When targeting adipose tissue:
  Transdermal delivery of the cocktail through Ultrapeel® Transderm Meso® system. In this way. Deliver every 2 weeks for 3 treatments. Thereafter every 6-8 weeks for maintenance. Prepare solution using a 10 cc syringe. After combining the ingredients transfer half of the solution to another 10 cc syringe. Use 1 syringe per side of the face.
  2 cc Sodium Hyaluronate 25 mg/mL
  2 cc Glutathione 100 mg/mL
  2 cc MTE 4 containing: (1 mg copper, 0.5 mg manganese, 10 mcg chromium, 22 mg zinc sulfate) per mL

Application of proper follow up at the end

Results & Conclusions

• Patients were treated with the following results: Patients drastically reduced inches in weeks.
• Transdermal delivery is possible and safe with no contraindications reported.
• All patients showed a good level of improvement and she was so happy with results.